Andropause Mastery

Conclusion: Statins, testosterone and PDE-5 inhibitor treatment reduces mortality in diabetic men.
Key observation: There is significant synergism with combined treatment modalities that is astounding!
Individual treatment strategies did not reduce mortality as singular interventions.
Biggest drop in mortality is from prescribing of PDE-5 inhibitors.

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Incorrect

Question 4 of 6

4. Question

The second study on diabetics: Statin, testosterone, and phosphodiesterase inhibitor treatments and age-related mortality in diabetes.

To determine how statins, testosterone replacement (TRT), and PDE-5 inhibitors influence age-related mortality in diabetic men.

Study: 857 diabetic men ages 50–80 for 3.8 year follow-up.

Treatment of Patients with Diabetes

Mortality – Statin, Untreated vs Treated	Mortality – Testosterone: Untreated vs Treated
*Mortality – PDE-5 Inhibitors: Untreated vs Treated*	Mortality Untreated vs All Three Treatments

Mortality – Statin, Untreated vs Treated

mortality - statin

Mortality – Testosterone: Untreated vs Treated

mortality - testosterone

Mortality – PDE-5 Inhibitors: Untreated vs Treated

mortality - PDE-5

Mortality Untreated vs All Three Treatments

mortality - untreated

PDE-5 physiology (choose incorrect answer):

cGMP and cAMP are metabolized by various Phosphodiesterase (PDE) enzymes – PDE-5 is the major enzyme degrading cGMP
Deficiency of cGMP can come from either lack of NO or decreased Guanylyl cyclase (sGC) activity or from over-activity of the PDE-5 enzymes
PDE enzyme activity tends to decrease with increasing age
NO from vascular eNOS from dietary Nitrate or from L-Arginine/l-Citrulline amino acids induces sGC that produces cGMP/cAMP
eNOS is primarily activated by estrogens derived from testosterone or DHEA – both sources reduced with aging
Inflammation activates iNOS that shifts available NO into ROS primarily peroxynitrite that reduces sGC activity and available cGMP/cAMP
Aging, inflammation (ROS) and diseases are clearly reliant on adequate cGMP/cAMP to maintain basic physiologic cell functions

Correct

Incorrect

Question 5 of 6

5. Question

The second study on diabetics: Statin, testosterone, and phosphodiesterase inhibitor treatments and age-related mortality in diabetes.

To determine how statins, testosterone replacement (TRT), and PDE-5 inhibitors influence age-related mortality in diabetic men.

Study: 857 diabetic men ages 50–80 for 3.8 year follow-up.

Treatment of Patients with Diabetes

Mortality – Statin, Untreated vs Treated	Mortality – Testosterone: Untreated vs Treated
*Mortality – PDE-5 Inhibitors: Untreated vs Treated*	Mortality Untreated vs All Three Treatments

Mortality – Statin, Untreated vs Treated

mortality - statin

Mortality – Testosterone: Untreated vs Treated

mortality - testosterone

Mortality – PDE-5 Inhibitors: Untreated vs Treated

mortality - PDE-5

Mortality Untreated vs All Three Treatments

mortality - untreated

Pathways for systemic health with PDE-5 Inhibitors (choose incorrect answer):

Deactivation of Cytochrome D activity thus increased vascular flow
Increased activation of endogenous stem cells (ie vascular periocytes and neural stem cells)
Increased average telomere length
Increased innate immunity, decreased acute infection and severity
Systemic vasodilation regulation that becomes dysregulated in all organs and tissues with increasing age
Decreased ROS and inflammatory pathways

Correct

Incorrect

Question 6 of 6

6. Question

The second study on diabetics: Statin, testosterone, and phosphodiesterase inhibitor treatments and age-related mortality in diabetes.

To determine how statins, testosterone replacement (TRT), and PDE-5 inhibitors influence age-related mortality in diabetic men.

Study: 857 diabetic men ages 50–80 for 3.8 year follow-up.

Treatment of Patients with Diabetes

Mortality – Statin, Untreated vs Treated	Mortality – Testosterone: Untreated vs Treated
*Mortality – PDE-5 Inhibitors: Untreated vs Treated*	Mortality Untreated vs All Three Treatments

Mortality – Statin, Untreated vs Treated

mortality - statin

Mortality – Testosterone: Untreated vs Treated

mortality - testosterone

Mortality – PDE-5 Inhibitors: Untreated vs Treated

mortality - PDE-5

Mortality Untreated vs All Three Treatments

mortality - untreated

Pathways for systemic health with PDE-5 Inhibitors (choose incorrect answer):

Balance of cGMP vs cAMP is critical to normalized systemic physiology and are regulated by the many PDE inhibitors
Increased apoptotic pathways for early cancer protection and response on most treatments today
Improved diabetes, heart disease, and cancer outcomes
Augmenting of cell proliferating activity

Correct

Incorrect

Andropause Mastery

Quiz 17: The Major Anti-aging Breakthroughs of the PDE-5 Inhibitors: Overview

Quiz Summary

Information

Results

Results

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1. Question

2. Question

3. Question

Treatment of Patients with Diabetes

4. Question

Treatment of Patients with Diabetes

5. Question

Treatment of Patients with Diabetes

6. Question

Treatment of Patients with Diabetes